The Proficient translates o opoudaios, and means the achieved Mystic, the Adept, almost the ‘Uniate’, the human being who has become ‘wholly the Divine’.
And the Proficient [the Sage], how does he stand with regard to magic and philtre-spells? In the soul he is immune from magic; his reasoning part cannot be touched by it, he cannot be perverted. But there is in him the unreasoning element which comes from the [material] All, and in this he can be affected, or rather this can be affected in him. Philtre-Love, however, he will not know, for that would require the consent of the higher soul to the trouble stiffed in the lower. And, just as the unreasoning element responds to the call of incantation, so the adept himself will dissolve those horrible powers by counter-incantations. Death, disease, any experience within the material sphere, these may result, yes; for anything that has membership in the All may be affected by another member, or by the universe of members; but the essential man is beyond harm. Ennead IV,4,